The CHiP trial
Welcome to the CHiP trial website.
The CHiP trial is investigating if strict control of the blood glucose levels of young people in paediatric intensive care units is beneficial when compared to current standard practices. This trial would not be possible without the hard work of the PICUs or the patients and their parents/guardians.
The information provided is aimed at participating sites, parents and the wider research community and we hope you find this website helpful and informative.
  • We’re delighted to say that the main CHiP trial paper has just been published:
    Macrae D, Grieve R, Allen E, Sadique Z, Morris K, Pappachan J, Parslow R, Tasker RC, Elbourne D; CHiP Investigators. A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med. 2014 Jan 9;370(2):107-18. doi: 10.1056/NEJMoa1302564. PMID: 24401049
    The pubmed citation is: This links to the abstract. There was also an editorial. The HTA monograph will be published later in the year.
  • The 1000th patient was recruited on the 2nd of December 2010!
  • Newsletters 1, 2, 3, 4, 5 and 6 are now available, see Newsletters.
  • Frequently Asked Questions, click here.
Use the menu on the left to navigate around this site.
Number of patients randomised : 1384

As of 1st of September 2011 the trial closed to recruitment

Cumulative CHiP Recruitment by Month of Randomisation